What is the primary cause of giant-cell papillary conjunctivitis in contact lens wearers?

Giant-cell papillary conjunctivitis (GPC) is primarily associated with chronic irritation caused by the presence of contact lenses on the ocular surface. This condition often develops when the eyelid comes into contact with the undersurface of a contact lens, leading to inflammation and the formation of giant papillae. The consistent friction and irritation from the contact lens can stimulate an inflammatory response, causing the conjunctiva to develop these papillary formations.

Although allergic reactions to lens solutions and mechanical irritation from lens edges can also lead to eye discomfort or inflammation, they are not the primary causes of GPC. Additionally, wearing contact lenses for short periods does not contribute to the development of this condition, as GPC is typically linked to extended wear and improper lens hygiene, which exacerbate chronic irritation. Thus, understanding the mechanism of irritation involved in GPC is crucial for effective management and prevention in contact lens wearers.